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Abstract
This study describes the effect of a biologic currently under development for the treatment of osteoarthritis to induce both cytoskeletal and transcriptional changes in bone marrow-derived mesenchymal stem cells. These changes may have implications for the regenerative potential of low molecular weight fraction of commercial 5% human serum albumin and could help explain some of the clinical findings in the clinical trials conducted using this drug.
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Details
1 Swedish Medical Center, Trauma Research Department, Englewood, Colorado, USA; St. Anthony Hospital, Trauma Research Department, Lakewood, Colorado, USA; Medical Center of Plano, Trauma Research Department, Plano, Texas, USA; Ampio Pharmaceuticals Inc., Englewood, Colorado, USA
2 Swedish Medical Center, Trauma Research Department, Englewood, Colorado, USA; Ampio Pharmaceuticals Inc., Englewood, Colorado, USA
3 New York Blood Center, New York, New York, USA
4 SomaLogic Inc., Boulder, Colorado, USA