Abstract

Micro-computed tomography and histomorphometry showed that bone formation was significantly higher in mice treated with constitutively active ALK2 (caALK2)-expressing adipose-derived stem cells (ASCs) in vivo. Using a novel transgenic mouse model, expression of caALK2 receptor was found to significantly increase ASC osteogenic differentiation. The results demonstrate that this increased ASC differentiation can be harnessed to improve calvarial healing.

Details

Title
Targeting of ALK2, a Receptor for Bone Morphogenetic Proteins, Using the Cre/lox System to Enhance Osseous Regeneration by Adipose-Derived Stem Cells
Author
Peterson, Jonathan R 1 ; Eboda Oluwatobi 1 ; Agarwal Shailesh 1 ; Ranganathan Kavitha 1 ; Buchman, Steven R 1 ; Lee, Min 2 ; Wang, Stewart C 1 ; Mishina Yuji 3 ; Levi, Benjamin 4 

1  Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA 
2  Division of Advanced Prosthodontics, Biomaterials, and Hospital Dentistry, University of California, Los Angeles, Los Angeles, California, USA 
3  Department of Biologic and Materials Sciences, University of Michigan Dental School, Ann Arbor, Michigan, USA 
4  Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA 
Pages
1375-1380
Section
Tissue Engineering and Regenerative Medicine
Publication year
2014
Publication date
Nov 2014
Publisher
Oxford University Press
ISSN
21576564
e-ISSN
21576580
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.5966/sctm.2014-0082
ProQuest document ID
2299130676
Copyright
© 2014. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.