Abstract

Whether it is in radiobiology to identify DNA lesions or in medicine to adapt the radiotherapeutic protocols, a detailed understanding of the radiation-induced interactions in living matter is required. Monte Carlo track-structure codes have been successfully developed to describe these interactions and predict the radiation-induced energy deposits at the nanoscale level in the medium of interest. In this work, the quantum-mechanically based Monte Carlo track-structure code TILDA-V has been used to compute the slowing-down of protons in water and DNA. Stopping power and range are then reported and compared with existing data. Then, a first application of TILDA-V to cellular irradiations is also reported in order to highlight the absolute necessity of taking into account a realistic description of the cellular environment in microdosimetry.

Details

Title
Proton transport modeling in a realistic biological environment by using TILDA-V
Author
Alcocer-Ávila, Mario E 1   VIAFID ORCID Logo  ; Quinto, Michele A 2   VIAFID ORCID Logo  ; Monti, Juan M 2   VIAFID ORCID Logo  ; Rivarola, Roberto D 2 ; Champion, Christophe 1 

1  CELIA, Centre Lasers Intenses et Applications, Université de Bordeaux – CNRS – CEA, Talence, France 
2  Instituto de Física Rosario, CONICET – Universidad Nacional de Rosario, Rosario, Argentina 
Pages
1-18
Publication year
2019
Publication date
Oct 2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-019-50270-5
ProQuest document ID
2299752366
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.