Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance

There are a number of errors in the caption for Fig 3, “Ingenuity pathway analysis of concordantly changed mRNAs from Table 3,” panels A-D. Please see the complete, correct Fig 3 caption here.

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Fig 3. Ingenuity pathway analysis of concordantly changed mRNAs from Table 3.

Colors indicate predicted effect of transcript on biological function or disease in center of circular diagram. (A) Failure of heart. (B) Dysfunction of heart. (C) Cell death of heart. (D) Fibrosis of heart.

https://doi.org/10.1371/journal.pone.0224389.g001

The caption listed within Supporting Information file S1 Text is incorrect. Additionally, there are a number of errors in the gene names in S2 Table, S3 Table and S4 Table. Please view the correct S1 Text, S2 Table, S3 Table and S4 Table below.

Note, there is an error in the caption for S3 Table. Please see the complete, correct S3 Table caption below.

Supporting information

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S1 Text

. List of abbreviations and acronyms.

A-S

- All-subjects cohort, N = 47 (31 Responders and 11 Nonresponders)

C

cpT

-

Total Cross-Platform Concordance

C

ccT

- Total Cross-cohort concordance

DEG

- Differentially expressed genes

FPKM

- Fragments per kilobase of transcript per million mapped reads

HFrEF

-

Heart failure with reduced left ventricular ejection fraction

HFpEF

- Heart failure with preserved left ventricular ejection fraction

IPA

- Ingenuity Pathway Analysis

LVEF

- Left ventricular ejection fraction

LOCF

- last observation carried forward

NR

– Nonresponder for reverse remodeling, not meeting the definition of Responder in the A-S

cohort

POG

-

Percentage of overlapping genes

R

- Responder for reverse remodeling, predefined as an LVEF increase from baseline at 3

months of ≥5 absolute %, or an increase at 12 months of ≥8 absolute %.

R/NR

- Responder mRNA abundance change from baseline/Nonresponder change

RVEF

- Right ventricular ejection fraction

SAMGE-PC

- sequential analysis of myocardial gene expression with phenotypic change

S-R

-

Super-Responder subcohort, N = 12 (6 Super-Responders and 6 Nonresponders)

SR

- Super-Responder for reverse remodeling, predefined as an LVEF increase from baseline

at 3 or 12 months of ≥10 absolute %

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S1 Text. List of abbreviations and acronyms.

https://doi.org/10.1371/journal.pone.0224389.s001

(DOCX)

S2 Table. Up or downregulated genes within the R and R/NR analyses, microarray or RNA-Seq measurements in the S-R cohort.

https://doi.org/10.1371/journal.pone.0224389.s002

(DOCX)

S3 Table. Biologic categories of 299 concordant gene expression changes identified in the R/NR analysis by microarray and RNA-Seq in the S-R cohort (Table 3), and RT-qPCR and RNA-Seq in the S-R cohort (Table 2).

https://doi.org/10.1371/journal.pone.0224389.s003

(DOCX)

S4 Table. Up or downregulated genes within the R and R/NR analyses, microarray measurements in the A-S cohort.

https://doi.org/10.1371/journal.pone.0224389.s004

(DOCX)

References

1. Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, et al. (2019) Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS ONE 14(8): e0221519. https://doi.org/10.1371/journal.pone.0221519 pmid:31469842