Abstract

Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.

Details

Title
A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
Author
Hong-Wei, An 1 ; Li-Li, Li 2 ; Wang, Yi 3 ; Wang, Ziqi 4 ; Hou, Dayong 4 ; Yao-Xin, Lin 3 ; Sheng-Lin, Qiao 3 ; Man-Di, Wang 3 ; Yang, Chao 2 ; Cong, Yong 3 ; Yang, Ma 3 ; Xiao-Xiao, Zhao 3 ; Cai, Qian 2 ; Wen-Ting, Chen 2 ; Chu-Qi, Lu 2 ; Xu, Wanhai 4 ; Wang, Hao 3 ; Zhao, Yuliang 5   VIAFID ORCID Logo 

1  CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, China; Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, China 
2  CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, China 
3  CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, China 
4  Department of Urology, The Fourth Hospital of Harbin Medical University, Heilongjiang Key Laboratory of Scientific Research in Urology, Harbin, China 
5  CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, China; Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, China 
Pages
1-15
Publication year
2019
Publication date
Oct 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-019-12848-5
ProQuest document ID
2309515003
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.