Details
Title
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
Author
Gallagher, C S 1 ; Mäkinen, N 2 ; Harris, H R 3 ; Rahmioglu, N 4 ; Uimari, O 5
; Cook, J P 6 ; Shigesi, N 7 ; Ferreira, T 8 ; Velez-Edwards, D R 9 ; Edwards, T L 10
; Mortlock, S 11 ; Ruhioglu, Z 2
; Day, F 12
; Becker, C M 7
; Karhunen, V 13 ; Martikainen, H 14 ; M-R Järvelin 15
; Cantor, R M 16 ; Ridker, P M 17 ; Terry, K L 18 ; Buring, J E 17 ; Gordon, S D 19
; Medland, S E 20
; Montgomery, G W 21
; Nyholt, D R 22
; Hinds, D A 23
; Tung, J Y 23 ; Agee, Michelle 23 ; Alipanahi, Babak 23 ; Auton, Adam 23 ; Bell, Robert K 23 ; Bryc, Katarzyna 23 ; Elson, Sarah L 23 ; Fontanillas, Pierre 23 ; Furlotte, Nicholas A 23 ; Huber, Karen E 23 ; Kleinman, Aaron 23 ; Litterman, Nadia K 23 ; McIntyre, Matthew H 23 ; Mountain, Joanna L 23 ; Noblin, Elizabeth S 23 ; Northover, Carrie A M 23 ; Pitts, Steven J 23 ; Sathirapongsasuti, J Fah 23 ; Sazonova, Olga V 23 ; Shelton, Janie F 23 ; Shringarpure, Suyash 23 ; Tian, Chao 23 ; Vacic, Vladimir 23 ; Wilson, Catherine H 23 ; Perry, J R B 12 ; Lind, P A 20
; Painter, J N 20 ; Martin, N G 19
; Morris, A P 24 ; Chasman, D I 17 ; Missmer, S A 25 ; Zondervan, K T 26
; Morton, C C 27
1 Department of Genetics, Harvard Medical School, Boston, MA, USA
2 Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
4 Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
5 Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK; Department of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
6 Department of Biostatistics, University of Liverpool, Liverpool, UK
7 Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK
8 Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Big Data Institute, Li Ka Shing Center for Health Information and Discovery, Oxford University, Oxford, UK
9 Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA
10 Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA
11 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
12 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK
13 Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
14 Department of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
15 Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, Middlesex, UK
16 Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
17 Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
18 Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
19 Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
20 Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
21 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
22 Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia
23 23andMe, Mountain View, CA, USA
24 Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Department of Biostatistics, University of Liverpool, Liverpool, UK
25 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA
26 Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK
27 Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Manchester Centre for Audiology and Deafness, Manchester Academic Health Science Center, University of Manchester, Manchester, UK
; Cook, J P 6 ; Shigesi, N 7 ; Ferreira, T 8 ; Velez-Edwards, D R 9 ; Edwards, T L 10
; Mortlock, S 11 ; Ruhioglu, Z 2
; Day, F 12
; Becker, C M 7
; Karhunen, V 13 ; Martikainen, H 14 ; M-R Järvelin 15
; Cantor, R M 16 ; Ridker, P M 17 ; Terry, K L 18 ; Buring, J E 17 ; Gordon, S D 19
; Medland, S E 20
; Montgomery, G W 21
; Nyholt, D R 22
; Hinds, D A 23
; Tung, J Y 23 ; Agee, Michelle 23 ; Alipanahi, Babak 23 ; Auton, Adam 23 ; Bell, Robert K 23 ; Bryc, Katarzyna 23 ; Elson, Sarah L 23 ; Fontanillas, Pierre 23 ; Furlotte, Nicholas A 23 ; Huber, Karen E 23 ; Kleinman, Aaron 23 ; Litterman, Nadia K 23 ; McIntyre, Matthew H 23 ; Mountain, Joanna L 23 ; Noblin, Elizabeth S 23 ; Northover, Carrie A M 23 ; Pitts, Steven J 23 ; Sathirapongsasuti, J Fah 23 ; Sazonova, Olga V 23 ; Shelton, Janie F 23 ; Shringarpure, Suyash 23 ; Tian, Chao 23 ; Vacic, Vladimir 23 ; Wilson, Catherine H 23 ; Perry, J R B 12 ; Lind, P A 20
; Painter, J N 20 ; Martin, N G 19
; Morris, A P 24 ; Chasman, D I 17 ; Missmer, S A 25 ; Zondervan, K T 26
; Morton, C C 27
1 Department of Genetics, Harvard Medical School, Boston, MA, USA
2 Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
4 Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
5 Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK; Department of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
6 Department of Biostatistics, University of Liverpool, Liverpool, UK
7 Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK
8 Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Big Data Institute, Li Ka Shing Center for Health Information and Discovery, Oxford University, Oxford, UK
9 Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA
10 Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA
11 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
12 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK
13 Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
14 Department of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
15 Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, Middlesex, UK
16 Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
17 Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
18 Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
19 Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
20 Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
21 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
22 Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia
23 23andMe, Mountain View, CA, USA
24 Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Department of Biostatistics, University of Liverpool, Liverpool, UK
25 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA
26 Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK; Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK
27 Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Manchester Centre for Audiology and Deafness, Manchester Academic Health Science Center, University of Manchester, Manchester, UK
Pages
1-11
Publication year
2019
Publication date
Oct 2019
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2309520578
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.