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© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Individuals with osteoarthritis (OA) are at greater risk of cardiovascular and cerebrovascular incidents; yet, cerebrovascular control remains uncharacterized. Our primary outcome was to acquire cerebrovascular control metrics in patients with OA and compare measures to healthy control adults (CTL) without OA or cardiovascular complications. Our primary covariate was a 10‐year risk factor for cardiovascular and stroke incidents, and secondary covariates were other cardiovascular disease risk factors (i.e., body mass index, carotid intima media thickness, and brachial flow‐mediated dilation). Our secondary outcomes were to assess anatomical and functional changes that may be related to cerebrovascular reactivity were also acquired such as white matter lesion volume and brief cognitive assessments. In 25 adults (n = 13 CTL, n = 12 OA), under hypercapnia, magnetic resonance imaging (3T) was used to acquire a “Global Cerebrovascular Reactivity” index across the larger intracranial cerebral arteries and white matter lesions, and transcranial Doppler was used for both middle cerebral artery hemodynamic responses to hypercapnia and to assess autoregulation via a sit‐to‐stand task. Compared to CTL, OA had lower “Global Cerebrovascular Reactivity” index responses to hypercapnia, autoregulatory responses, and greater white matter lesions (P < 0.05). These differences persisted after covarying for the outlined primary and secondary covariates. Patients with OA, in the absence of known cardiovascular disease, can exhibit pre‐clinical and impaired (compared to CTL) peripheral and cerebrovascular control metrics.

Details

Title
Exploring Cerebrovascular Function in Osteoarthritis: “Heads‐up”
Author
Baraa K. Al‐Khazraji 1 ; Badrov, Mark B 2 ; Mason Kadem 3 ; Lingum, Navena R 2 ; Birmingham, Trevor B 4 ; Shoemaker, Joel Kevin 5   VIAFID ORCID Logo 

 School of Kinesiology, Faculty of Health Sciences, Western University, London, Ontario, Canada; Bone and Joint Institute, Western University, London, Ontario, Canada 
 School of Kinesiology, Faculty of Health Sciences, Western University, London, Ontario, Canada 
 Brain and Mind Institute, Western University, London, Ontario, Canada 
 School of Physical Therapy, Faculty of Health Sciences, Western Ontario, London, Ontario, Canada; Bone and Joint Institute, Western University, London, Ontario, Canada 
 School of Kinesiology, Faculty of Health Sciences, Western University, London, Ontario, Canada; Bone and Joint Institute, Western University, London, Ontario, Canada; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada 
Section
Original Research
Publication year
2019
Publication date
Oct 2019
Publisher
John Wiley & Sons, Inc.
e-ISSN
2051817X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2309664309
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.