Abstract

The association between suboptimal pre-pregnancy body mass index (BMI) and small-for-gestational-age (SGA) infants is not well defined. We investigated the association between pre-pregnancy BMI and the risk of SGA infants in a Chinese population. We performed a cohort study among 12029 mothers with a pregnancy. This cohort consisted of pregnant women that were: normal-weight (62.02%), underweight (17.09%), overweight (17.77%) and obese (3.12%). Birth sizes were reduced in the underweight and obese groups compared with the normal-weight group. Linear regression analysis indicated that birth size was positively associated with BMI in both the underweight and normal-weight groups. Further analysis showed that 12.74% of neonates were SGA infants in the underweight group, higher than 7.43% of neonates reported in the normal-weight group (adjusted RR = 1.92; 95% CI: 1.61, 2.30). Unexpectedly, 17.60% of neonates were SGA infants in the obese group, much higher than the normal-weight group (adjusted RR = 2.17; 95% CI: 1.57, 3.00). Additionally, 18.40% of neonates were large-for-gestational-age (LGA) infants in the obese group, higher than 7.26% of neonates reported in the normal-weight group (adjusted RR = 3.00; 95% CI: 2.21, 4.06). These results suggest that pre-pregnancy underweight increases the risk of SGA infants, whereas obesity increases the risks of not only LGA infants, but also SGA infants.

Details

Title
Pre-pregnancy underweight and obesity are positively associated with small-for-gestational-age infants in a Chinese population
Author
Chen, Yuan Hua 1 ; Li, Li 2 ; Chen, Wei 3 ; Liu, Zhi Bing 4 ; Li, Ma 4 ; Xing Xing Gao 3 ; Jia Liu He 4 ; Wang, Hua 4   VIAFID ORCID Logo  ; Zhao, Mei 5 ; Yuan Yuan Yang 2 ; De Xiang Xu 4   VIAFID ORCID Logo 

1  School of Basic Medical Sciences, Anhui Medical University, Hefei, China; School of Public Health, Anhui Medical University, Hefei, China; Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia 
2  Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China 
3  School of Basic Medical Sciences, Anhui Medical University, Hefei, China 
4  School of Public Health, Anhui Medical University, Hefei, China 
5  School of Nursing, Anhui Medical University, Hefei, China 
Pages
1-8
Publication year
2019
Publication date
Oct 2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-019-52018-7
ProQuest document ID
2310422993
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.