Abstract

We present an ultra-high resolution MRI dataset of an ex vivo human brain specimen. The brain specimen was donated by a 58-year-old woman who had no history of neurological disease and died of non-neurological causes. After fixation in 10% formalin, the specimen was imaged on a 7 Tesla MRI scanner at 100 µm isotropic resolution using a custom-built 31-channel receive array coil. Single-echo multi-flip Fast Low-Angle SHot (FLASH) data were acquired over 100 hours of scan time (25 hours per flip angle), allowing derivation of synthesized FLASH volumes. This dataset provides an unprecedented view of the three-dimensional neuroanatomy of the human brain. To optimize the utility of this resource, we warped the dataset into standard stereotactic space. We now distribute the dataset in both native space and stereotactic space to the academic community via multiple platforms. We envision that this dataset will have a broad range of investigational, educational, and clinical applications that will advance understanding of human brain anatomy in health and disease.

Alternate abstract:

Measurement(s)nuclear magnetic resonance assayTechnology Type(s)MRI ScannerFactor Type(s)flip angleSample Characteristic - OrganismHomo sapiens

Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.9958688

Details

Title
7 Tesla MRI of the ex vivo human brain at 100 micron resolution
Author
Edlow, Brian L 1   VIAFID ORCID Logo  ; Mareyam, Azma 2 ; Horn, Andreas 3   VIAFID ORCID Logo  ; Polimeni, Jonathan R 2   VIAFID ORCID Logo  ; Witzel, Thomas 2 ; Tisdall, M Dylan 4 ; Augustinack, Jean C 2 ; Stockmann, Jason P 2 ; Diamond, Bram R 2 ; Stevens, Allison 2 ; Tirrell, Lee S 2   VIAFID ORCID Logo  ; Folkerth, Rebecca D 5 ; Wald, Lawrence L 2 ; Fischl, Bruce 2 ; van der Kouwe, Andre 2 

1  Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Department of Neurology, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Charlestown, MA, USA 
2  Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Charlestown, MA, USA 
3  Movement Disorders & Neuromodulation Section, Department for Neurology, Charité – University Medicine Berlin, Berlin, Germany 
4  Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 
5  City of New York Office of the Chief Medical Examiner, and New York University School of Medicine, New York, NY, USA 
Pages
1-10
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20524463
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41597-019-0254-8
ProQuest document ID
2310639487
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.