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© 2018. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The filter could precisely control the electro-deposition thickness in the electroplating process, with a total thickness variation of less than 5%. [...]this electrochemical method could achieve a filter pore dimension deviation of less than 2 μm. The composition of the Pd–Ni alloy was evaluated using EDS analyses to examine the composition of the fabricated Pd–Ni alloy filter. [...]we can confirm that the Pd–Ni alloy membrane filter with a hardness approximating 553.5 Hv was more suitable than pure nickel with a hardness below 300 Hv. In vitro cytotoxicity testing to evaluate the biocompatibility of the fabricated micro-porous membrane filter is essential to assess, not only the filter itself, but also the safety and cytotoxic potential of the material passing through the filter. [...]cytotoxicity tests on the L-929 (mouse fibroblast) and A-549 (human alveolar basal epithelial cell) cells were conducted using two recommended methods, a direct contact method and an extract dilution method, according to the ISO 10993-5 standard; the methods were modified as described previously [28,29]. The electrical requirements of PZT were 14 V (rms) and 178 mA (rms). [...]power consumption was approximately 2.5 W. Figure 8 shows the characteristic diagrams of aerosol drops of various drug solutions.

Details

Title
Fabrication and Characterization of Medical Mesh-Nebulizer for Aerosol Drug Delivery
Author
Choi, Kyong-Hoon; Moon, Sang-Hyub; Su-Kang, Park; Cho, Guangsup; Ki Chang Nam; Park, Bong Joo
Publication year
2018
Publication date
Apr 2018
Publisher
MDPI AG
e-ISSN
20763417
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2314076892
Copyright
© 2018. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.