Details
Title
An MPER antibody neutralizes HIV-1 using germline features shared among donors
Author
Zhang, Lei 1 ; Irimia, Adriana 2 ; He, Lingling 3 ; Landais, Elise 4 ; Rantalainen, Kimmo 5 ; Leaman, Daniel P 6 ; Vollbrecht, Thomas 7
; Stano, Armando 6 ; Sands, Daniel I 6
; Kim, Arthur S 8
; Miiro, George 9 ; Serwanga, Jennifer 9 ; Pozniak, Anton 10 ; McPhee, Dale 11 ; Manigart, Oliver 12 ; Mwananyanda, Lawrence 12 ; Karita, Etienne 13 ; Inwoley, André 14 ; Jaoko, Walter 15 ; DeHovitz, Jack 16 ; Linda-Gail Bekker 17 ; Pitisuttithum, Punnee 18 ; Paris, Robert 19 ; Allen, Susan 20 ; Poignard, Pascal 21 ; Burton, Dennis R 22
; Murrell, Ben 23 ; Ward, Andrew B 2
; Zhu, Jiang 3 ; Wilson, Ian A 24
; Zwick, Michael B 6
1 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; CTK Biotech, Inc., Poway, California, USA
2 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; Scripps Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, USA
3 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA
4 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative, New York, New York, USA
5 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA
6 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA
7 Department of Medicine, University of California, San Diego, California, USA
8 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; Departments of Medicine, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
9 MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
10 St Stephens AIDS Trust, Chelsea and Westminster NHS Foundation Trust, London, UK
11 NRL, St Vincent’s Institute, Melbourne, Victoria, Australia
12 Zambia Emory HIV Research Project, Lusaka, Zambia and Rwanda-Zambia HIV Research Group, Emory University, Atlanta, GA, USA
13 Projet San Francisco, Kigali, Rwanda and the Rwanda-Zambia HIV Research Group, Emory University, Atlanta, GA, USA
14 CeDReS/CHU Treichville, Abidjan, Côte d’Ivoire
15 Kenya AIDS Vaccine Initiative, College of Health Sciences, University of Nairobi, Nairobi, Kenya
16 SUNY Downstate Medical Center, Brooklyn, New York, USA
17 Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
18 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
19 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
20 Rwanda-Zambia HIV Research Group, Emory University, Atlanta, Georgia, USA
21 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative, New York, New York, USA; Institut de Biologie Structurale, Université Grenoble Alpes, Commissariat a l’Energie Atomique, Centre National de Recherche Scientifique and Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
22 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; Scripps Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, USA; Ragon Institute of Massachusetts General Hospital, MIT and Harvard, Cambridge, Massachussetts, USA
23 Department of Medicine, University of California, San Diego, California, USA; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
24 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; Scripps Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
; Stano, Armando 6 ; Sands, Daniel I 6
; Kim, Arthur S 8
; Miiro, George 9 ; Serwanga, Jennifer 9 ; Pozniak, Anton 10 ; McPhee, Dale 11 ; Manigart, Oliver 12 ; Mwananyanda, Lawrence 12 ; Karita, Etienne 13 ; Inwoley, André 14 ; Jaoko, Walter 15 ; DeHovitz, Jack 16 ; Linda-Gail Bekker 17 ; Pitisuttithum, Punnee 18 ; Paris, Robert 19 ; Allen, Susan 20 ; Poignard, Pascal 21 ; Burton, Dennis R 22
; Murrell, Ben 23 ; Ward, Andrew B 2
; Zhu, Jiang 3 ; Wilson, Ian A 24
; Zwick, Michael B 6 1 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; CTK Biotech, Inc., Poway, California, USA
2 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; Scripps Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, USA
3 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA
4 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative, New York, New York, USA
5 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA
6 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA
7 Department of Medicine, University of California, San Diego, California, USA
8 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; Departments of Medicine, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
9 MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
10 St Stephens AIDS Trust, Chelsea and Westminster NHS Foundation Trust, London, UK
11 NRL, St Vincent’s Institute, Melbourne, Victoria, Australia
12 Zambia Emory HIV Research Project, Lusaka, Zambia and Rwanda-Zambia HIV Research Group, Emory University, Atlanta, GA, USA
13 Projet San Francisco, Kigali, Rwanda and the Rwanda-Zambia HIV Research Group, Emory University, Atlanta, GA, USA
14 CeDReS/CHU Treichville, Abidjan, Côte d’Ivoire
15 Kenya AIDS Vaccine Initiative, College of Health Sciences, University of Nairobi, Nairobi, Kenya
16 SUNY Downstate Medical Center, Brooklyn, New York, USA
17 Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
18 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
19 Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
20 Rwanda-Zambia HIV Research Group, Emory University, Atlanta, Georgia, USA
21 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative, New York, New York, USA; Institut de Biologie Structurale, Université Grenoble Alpes, Commissariat a l’Energie Atomique, Centre National de Recherche Scientifique and Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
22 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; Scripps Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, USA; Ragon Institute of Massachusetts General Hospital, MIT and Harvard, Cambridge, Massachussetts, USA
23 Department of Medicine, University of California, San Diego, California, USA; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
24 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, California, USA; Scripps Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
Pages
1-16
Publication year
2019
Publication date
Nov 2019
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2318717826
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.