Abstract

Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ in their clinical and molecular features. An investigation of differentially expressed genes (DEGs) between RCC and LCC could contribute to targeted therapy for colon cancer, especially RCC, which has a poor prognosis. Here, we identified HOXB13, which was significantly less expressed in RCC than in LCC and associated with prognosis in RCC, by using 5 datasets from the Gene Expression Omnibus (GEO). Tissue sample analysis showed that HOXB13 was differentially expressed between normal and only RCC tumor tissues. HOXB13 inhibited colon cancer cell proliferation and induced apoptosis both in vitro and in vivo. Furthermore, we found that HOXB13 might be regulated by DNMT3B and suppress C-myc expression to exert antitumor effects via β-catenin/TCF4 signals in RCC. In conclusion, the current study is the first to demonstrate that HOXB13 has a tumor-suppressive effect in RCC. High expression levels of HOXB13 are associated with prolonged overall survival in patients with RCC. The DNMT3B-HOXB13-C-myc signaling axis might be a molecular target for the treatment of RCC.

Details

Title
Tumor-suppressive function and mechanism of HOXB13 in right-sided colon cancer
Author
Xie Binbin 1 ; Bai Bingjun 2 ; Xu Yuzi 3   VIAFID ORCID Logo  ; Liu, Yunlong 1 ; Lv Yiming 2   VIAFID ORCID Logo  ; Gao Xing 4 ; Wu, Fei 5 ; Fang Zhipeng 1 ; Lou, Ying 1 ; Pan Hongming 1 ; Han, Weidong 1 

1  Zhejiang University, Department of Medical Oncology; Sir Run Run Shaw Hospital; School of Medicine, Hangzhou, PR China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) 
2  Zhejiang University, Department of Colorectal Surgery; Sir Run Run Shaw Hospital; School of Medicine, Hangzhou, PR China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) 
3  Zhejiang University, Department of Stomatology; Stomatology Hospital; School of Medicine, Hangzhou, PR China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) 
4  Suzhou University, Department of Medical Oncology; The Second Affiliated Hospital of Suzhou University; School of Medicine, Suzhou, PR China (GRID:grid.263761.7) (ISNI:0000 0001 0198 0694) 
5  Anhui University of Science and Technology, School of Medicine, Huainan, PR China (GRID:grid.440648.a) (ISNI:0000 0001 0477 188X) 
Publication year
2019
Publication date
2019
Publisher
Nature Publishing Group
ISSN
20959907
e-ISSN
20593635
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41392-019-0086-1
ProQuest document ID
2319482255
Copyright
© The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.