Details
Title
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
Author
Luengo, Alba 1
; Abbott, Keene L 1
; Davidson, Shawn M 2 ; Hosios, Aaron M 1 ; Faubert, Brandon 3
; Sze Ham Chan 4 ; Freinkman, Elizaveta 4 ; Zacharias, Lauren G 3 ; Mathews, Thomas P 5 ; Clish, Clary B 6
; DeBerardinis, Ralph J 7 ; Lewis, Caroline A 4
; Vander Heiden, Matthew G 8
1 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
2 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA
3 Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
4 Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA
5 Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
6 Broad Institute of MIT and Harvard University, Cambridge, MA, USA
7 Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA
8 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA
; Abbott, Keene L 1
; Davidson, Shawn M 2 ; Hosios, Aaron M 1 ; Faubert, Brandon 3
; Sze Ham Chan 4 ; Freinkman, Elizaveta 4 ; Zacharias, Lauren G 3 ; Mathews, Thomas P 5 ; Clish, Clary B 6
; DeBerardinis, Ralph J 7 ; Lewis, Caroline A 4
; Vander Heiden, Matthew G 8
1 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
2 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA
3 Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
4 Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA
5 Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
6 Broad Institute of MIT and Harvard University, Cambridge, MA, USA
7 Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA
8 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA
Pages
1-11
Publication year
2019
Publication date
Dec 2019
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2322188008
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.