Abstract

Imaging: probing chemical bonds

A phase imaging technique that provides spectroscopic chemical information could bring new opportunities for studying biology and materials science. Delong Zhang, Lu Lan, and coworkers from Boston, Illinois and Shanghai have developed a scheme called bond-selective transient phase (BSTP) imaging. The approach uses nanosecond pulses of mid-infrared pump laser light to excite molecular vibrations in the sample. The mid-infrared light absorption causes a small temperature change in the sample which results in a change of refractive index and thus a transient phase shift, which is read out by a burst of visible probe pulses and a CMOS camera. Tests with samples including a thin oil film, polyurethane beads, living cells, and the interface between two liquids (olive oil and dimethyl sulfoxide) indicate that BSTP imaging can operate with sub-microsecond temporal resolution and sub-micrometer spatial resolution.

Details

Title
Bond-selective transient phase imaging via sensing of the infrared photothermal effect
Author
Delong, Zhang 1   VIAFID ORCID Logo  ; Lu, Lan 2 ; Bai, Yeran 3 ; Majeed, Hassaan 4   VIAFID ORCID Logo  ; Kandel, Mikhail E 5   VIAFID ORCID Logo  ; Popescu, Gabriel 6   VIAFID ORCID Logo  ; Ji-Xin, Cheng 7   VIAFID ORCID Logo 

1  Department of Biomedical Engineering, Boston University, Boston, MA, USA; Department of Physics, Zhejiang University, Hangzhou, China 
2  Department of Biomedical Engineering, Boston University, Boston, MA, USA 
3  Department of Biomedical Engineering, Boston University, Boston, MA, USA; National Laboratory on High Power Laser and Physics, Shanghai, China; Key Laboratory of High Power Laser and Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai, China 
4  Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, IL, USA 
5  Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL, USA 
6  Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, IL, USA; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL, USA 
7  Department of Biomedical Engineering, Boston University, Boston, MA, USA; Department of Electrical & Computer Engineering, Boston University, Boston, MA, USA; Photonics Center, Boston University, Boston, MA, USA 
Pages
1-12
Publication year
2019
Publication date
Dec 2019
Publisher
Springer Nature B.V.
e-ISSN
20477538
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41377-019-0224-0
ProQuest document ID
2323446238
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.