Abstract

The adipokine leptin modulates intestinal inflammation in mice. Here the authors describe a patient with inflammatory bowel disease and lipodystrophy, providing evidence that leptin aggravates intestinal inflammation with proinflammatory effects on leukocytes that are reversible by TNFα blockade.

Details

Title
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
Author
Ziegler, Jörn F 1 ; Böttcher, Chotima 2   VIAFID ORCID Logo  ; Letizia, Marilena 1 ; Yerinde, Cansu 1 ; Wu, Hao 1 ; Freise, Inka 1 ; Rodriguez-Sillke, Yasmina 1   VIAFID ORCID Logo  ; Stoyanova, Ani K 3 ; Kreis, Martin E 3 ; Asbach, Patrick 4 ; Kunkel, Desiree 5   VIAFID ORCID Logo  ; Priller, Josef 6 ; Anagnostopoulos, Ioannis 7 ; Kühl, Anja A 8 ; Miehle, Konstanze 9 ; Stumvoll, Michael 9 ; Tran, Florian 10 ; Fredrich, Broder 10 ; Forster, Michael 10   VIAFID ORCID Logo  ; Franke, Andre 10   VIAFID ORCID Logo  ; Bojarski, Christian 1 ; Glauben, Rainer 1 ; Britt-Sabina Löscher 10   VIAFID ORCID Logo  ; Siegmund, Britta 1   VIAFID ORCID Logo  ; Weidinger, Carl 11   VIAFID ORCID Logo 

 Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Berlin, Germany 
 Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Laboratory of Molecular Psychiatry and Department of Neuropsychiatry, Berlin, Germany 
 Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Department of Visceral Surgery, Campus Benjamin Franklin, Berlin, Germany 
 Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Department of Radiology, Campus Benjamin Franklin, Berlin, Germany 
 Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; BIH Cytometry Core, Berlin Institute of Health, Berlin, Germany 
 Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Laboratory of Molecular Psychiatry and Department of Neuropsychiatry, Berlin, Germany; BIH Berlin, DZNE Berlin and University of Edinburgh and UK DRI, Edinburgh, UK 
 Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Department of Pathology, Campus Charité Mitte, Berlin, Germany 
 Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; iPATH.Berlin–Immunopathology for Experimental Models, Core Facility of the Charité, Berlin, Germany 
 Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany 
10  Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany 
11  Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Berlin, Germany; Clinician Scientist Program, Berlin Institute of Health, Berlin, Germany 
Pages
1-11
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2323448661
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.