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Abstract
The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.
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1 IFOM (Istituto FIRC di Oncologia Molecolare), Milan, Italy
2 IFOM (Istituto FIRC di Oncologia Molecolare), Milan, Italy; Università degli Studi di Milano, Milan, Italy