Abstract

Household income is used as a marker of socioeconomic position, a trait that is associated with better physical and mental health. Here, Hill et al. report a genome-wide association study for household income in the UK and explore its relationship with intelligence in post-GWAS analyses including Mendelian randomization.

Details

Title
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income
Author
Hill, W David 1 ; Davies, Neil M 2   VIAFID ORCID Logo  ; Ritchie, Stuart J 3 ; Skene, Nathan G 4   VIAFID ORCID Logo  ; Bryois, Julien 5   VIAFID ORCID Logo  ; Bell, Steven 6   VIAFID ORCID Logo  ; Emanuele Di Angelantonio 7 ; Roberts, David J 8 ; Shen Xueyi 9   VIAFID ORCID Logo  ; Davies, Gail 1 ; Liewald, David C M 1   VIAFID ORCID Logo  ; Porteous, David J 10   VIAFID ORCID Logo  ; Hayward, Caroline 11   VIAFID ORCID Logo  ; Butterworth, Adam S 6   VIAFID ORCID Logo  ; McIntosh, Andrew M 12   VIAFID ORCID Logo  ; Gale, Catharine R 13   VIAFID ORCID Logo  ; Deary, Ian J 1 

 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK 
 Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Bristol Medical School, University of Bristol, Bristol, UK 
 Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK 
 Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; UCL Institute of Neurology, London, UK; Department of Medicine, Division of Brain Sciences, Imperial College, London, UK 
 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden 
 The National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK; UK Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge, UK 
 The National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Cambridge, UK; UK Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge, UK; NHS Blood and Transplant, Cambridge, UK 
 Cambridge Substantive Site, Health Data Research UK, Hinxton, UK; BRC Haematology Theme and Radcliffe Department of Medicine, University of Oxford, Oxford, UK; NHS Blood and Transplant – Oxford Centre, Oxford, UK 
 Division of Psychiatry, University of Edinburgh, Edinburgh, UK 
10  Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK 
11  MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK 
12  Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Division of Psychiatry, University of Edinburgh, Edinburgh, UK 
13  Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK 
Pages
1-16
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2327336767
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.