Abstract

Anticancer drugs often have widespread effects on the cellular proteome. Here, the authors generate a proteome signature library of drug-treated cancer cell lines and develop a software tool to deconvolute drug targets and gain insights into their mechanisms of action.

Details

Title
ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
Author
Amir Ata Saei 1   VIAFID ORCID Logo  ; Christian Michel Beusch 1   VIAFID ORCID Logo  ; Chernobrovkin, Alexey 2   VIAFID ORCID Logo  ; Sabatier, Pierre 1   VIAFID ORCID Logo  ; Zhang, Bo 3   VIAFID ORCID Logo  ; Ülkü Güler Tokat 4 ; Stergiou, Eleni 1   VIAFID ORCID Logo  ; Gaetani, Massimiliano 5   VIAFID ORCID Logo  ; Végvári, Ákos 1   VIAFID ORCID Logo  ; Zubarev, Roman A 6 

1  Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden 
2  Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Pelago Bioscience AB, Solna, Sweden 
3  Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden 
4  Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Faculty of Science, Department of Chemistry, Hacettepe University, Ankara, Turkey 
5  Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; SciLifeLab, SE-17 177, Stockholm, Sweden 
6  Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; SciLifeLab, SE-17 177, Stockholm, Sweden; Department of Pharmacological & Technological Chemistry, Sechenov First Moscow State Medical University, Moscow, Russia 
Pages
1-13
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-019-13582-8
ProQuest document ID
2327337376
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.