Abstract

Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1–2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease.

Trial registration

NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.

Details

Title
Relationship between diffusion capacity and small airway abnormality in COPDGene
Author
Criner, Rachel N; Hatt, Charles R; Galbán, Craig J; Kazerooni, Ella A; Lynch, David A; McCormack, Meredith C; Casaburi, Richard; Neil R MacIntyrerry J Make; Martinez, Fernando J; Labaki, Wassim W; Curtis, Jeffrey L; Han, Mei Lan K
Pages
1-4
Section
Letter to the Editor
Publication year
2019
Publication date
2019
Publisher
BioMed Central
ISSN
1465993X
e-ISSN
14659921
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s12931-019-1237-1
ProQuest document ID
2328254925
Copyright
© 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.