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© 2019. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Objectives

Oropharyngeal squamous cell carcinoma (OPSCC) incidence is rapidly increasing in the United States and around the world, driven in large part by infection with the human papillomavirus (HPV). HPV associated OPSCC (HPV+OPSCC) has been shown to have improved response to treatment relative to tobacco‐associated OPSCC. However, improvement in patient survival has not been uniform. Subsets of OPSCC patients in the US and around the world continue to have poor oncologic outcomes. Although the drivers of this phenomenon remain unclear, there is increasing evidence that tobacco exposure plays an important role in modulating HPV+OPSCC clinical outcomes.

Methods

We conducted a review of the literature.

Results

We discuss the potential biological and epidemiological interplay between tobacco and HPV exposure in the context of OPSCC. Multiple retrospective and prospective cohorts show that HPV+OPSCC patients with a history of tobacco exposure have response to treatment and clinical outcomes distinct from HPV+OPSCC non‐smokers which poses clinical and scientific challenges to be addressed over the next decade.

Conclusions

The interaction between tobacco exposure and HPV infection in the context of OPSCC has significant implications for both standard of care treatment regimens and development of novel therapeutic approaches, in particular those which incorporate immunomodulatory agents.

Level of Evidence

5

Details

Title
A Hidden Epidemic of “Intermediate Risk” Oropharynx Cancer
Author
Sandulache, Vlad C 1   VIAFID ORCID Logo  ; Wilde, David C 2 ; Sturgis, Erich M 3 ; Chiao, Elizabeth Y 4 ; Sikora, Andrew G 1 

 Bobby R. Alford Department of Otolaryngology–Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.; ENT Section, Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, U.S.A. 
 Bobby R. Alford Department of Otolaryngology–Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A. 
 Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A. 
 Department of Medicine, Baylor College of Medicine, Houston, Texas, U.S.A. 
Pages
617-623
Section
HEAD AND NECK, AND TUMOR BIOLOGY
Publication year
2019
Publication date
Dec 2019
Publisher
John Wiley & Sons, Inc.
e-ISSN
23788038
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2330046383
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.