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© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

If acting in concert, this might be indicative of shared pathogenic mechanisms leading to CVD risk. [...]in an earlier report from the Prevention of Renal and Vascular Endstage Disease (PREVEND) study [10], statistical interactions of elevated UAE with multiple apoB-containing lipoprotein fractions were demonstrated, leading to the conclusion that elevated UAE and atherogenic apoB lipoproteins characteristic of albuminuric subjects likely do share common pathogenic mechanisms leading to CVD. [...]in the current study, we hypothesized that various attributes of HDL particles might demonstrate modulation of the CVD risk associated with elevated UAE, which is potentially indicative of a commonality of pathogenic pathways. Results (Table 2) demonstrated significant interaction with UAE only for apoA-I/HDL-C. [...]when models were concurrently adjusted for gender, age, apoB concentration, diabetes, past CVD history, CRP concentration, and eGFR; again significant interaction with UAE was demonstrated only for apoA-I/HDL-C (Table 3). [...]multiple regression analysis with total apoA-I concentration as a function of large, medium, and small particles was used to estimate the mean number of apoA-I molecules/particle for the three subfractions (Appendix A).

Details

Title
Compositional Features of HDL Particles Interact with Albuminuria to Modulate Cardiovascular Disease Risk
Author
Corsetti, James P; Bakker, Stephan J L; Gansevoort, Ronald T; Gruppen, Eke G; Connelly, Margery A; Sparks, Charles E; Dullaart, Robin P F
Publication year
2019
Publication date
2019
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2332042977
Copyright
© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.