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© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction Normal physiological processes are maintained through a homeostatic balance between two very critical parts of the normal development and maturation cycle namely cell proliferation and cell death. Apoptosis is characterized by: a reduction in mitochondrial transmembrane potential, intracellular acidification, cell shrinkage, DNA fragmentation and condensation, production of reactive oxygen species, externalization of phosphatidylserine and selective proteolysis of a subset of cellular proteins [2]. Cytotoxicity Cancer cells accumulate multiple mutations in genes that regulate the cell cycle. Excessive production of reactive oxygen species can induce lipid peroxidation, depletion of sulfhydryl groups, altered signal transduction pathways, altered calcium homeostasis and DNA damage, which could lead to the induction of apoptosis [12].

Details

Title
In Vitro Anti-proliferative Activity and Mechanism of Action of Anemone nemorosa
Author
Swanepoel, Bresler; Venables, Luanne; Olaru, Octavian Tudorel; George Mihai Nitulescu; van de Venter, Maryna
Publication year
2019
Publication date
2019
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2332148849
Copyright
© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.