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© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

A study combining standard dexamethasone (GR activation) for leukemia treatment with add-on cortisol (concurrent MR activation), shows that MR activity is important for neuronal processes such as sleep cycle and mood regulation [8]. [...]it is of great relevance to characterize and enable selective modulation of MR-mediated effects, serving a potential antidepressant approach. [...]we assessed GR and Neurod2 binding at previously identified MR targets [9] in the hippocampus of forebrain-specific MR knockout mice (fbMRKO). GR and Neurod2 occupancy of MR-binding loci was measured by chromatin immunoprecipitation coupled with quantitative polymerase chain reaction (ChIP-qPCR) on hippocampus of wild-type (WT) and forebrain-specific mineralocorticoid receptor knockout (fbMRKO) mice. Where MyoD can induce both histone acetylation at H4 (chromatin remodeling) and in addition recruit RNA polymerase II (direct activation mediated by the transcriptional activation domain), Myf5 is only able to induce H4 acetylation as a manner to enhance transcription [12].

Details

Title
Mechanistic Insights in NeuroD Potentiation of Mineralocorticoid Receptor Signaling
Author
Lisa T C M van Weert; Buurstede, Jacobus C; Sips, Hetty C M; Mol, Isabel M; Puri, Tanvi; Damsteegt, Ruth; Roozendaal, Benno; Sarabdjitsingh, R Angela; Meijer, Onno C
Publication year
2019
Publication date
2019
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2332255691
Copyright
© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.