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© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

[...]the cAMP level in the cells was also reduced by treatment with rottlerin after induction with 100 nM of α-MSH (Figure 4b), which implied that rottlerin inhibited melanogenesis in melanoma cells by targeting cAMP/CREB signaling and reducing the process of melanin synthesis. 2.5. Since cAMP is upstream of CREB, and our results showed that cAMP level was significantly decreased after rottlerin treatment compared to arbutin treatment (a well-known commercially available skin whitening agent), we concluded that rottlerin inhibited melanogenesis in melanoma cells by reducing cAMP production. [...]in the human melanoma cell line SK-Mel 28, the presence of protective autophagy in the cell was found to cause the death of the cells by inhibition of mTORC1, resulting in protein loss [20]. [...]rottlerin—as an autophagy inducer—played a role in inhibiting melanogenesis by targeting cAMP in the cytosol through the cAMP/CREB signaling pathway (Figure 6).

Details

Title
Rottlerin Reduces cAMP/CREB-Mediated Melanogenesis via Regulation of Autophagy
Author
Qomaladewi, Nurinanda Prisky; Mi-Yeon, Kim; Cho, Jae Youl
Publication year
2019
Publication date
2019
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2332355115
Copyright
© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.