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© 2019. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

A series of works focusing on the application of cationic surfactants in drug delivery have been recently reviewed [27], with emphasis given to their use for gene therapy [28,29,30,31], as a template for the synthesis of mesoporous materials [32], and also to their biocidal action against bacteria and fungi [33,34]. Structural Diversity of Biocompatible and Ecologically Friendly Cationic Surfactants One of the promising approaches in the design of building blocks for biomedical applications, which include formulations for drug delivery, is the creation of new multifunctional environmentally friendly, cleavable, green, and less toxic cationic surfactant systems answering the biotechnological criteria and improving biocompatibility, solubility, bioavailability, and biodegradability of therapeutics [35,36,37]. The new class of biocompatible surfactants with polar head groups containing natural moiety such as sugar-, peptide-, and pyrimidine-bearing moieties are promising drug and gene carriers for intracellular delivery [40]. Importantly, they provide a widened spectrum of intermolecular interaction (hydrogen bonding, electrostatic, and van der Waals), stacking and complementary interactions upon self-assembly, and binding the drug, thereby combining high efficacy with lower toxicity [41,42].

Details

Title
Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications
Author
Lucia Ya Zakharova; Pashirova, Tatiana N; Doktorovova, Slavomira; Fernandes, Ana R; Sanchez-Lopez, Elena; Silva, Amélia M; Souto, Selma B; Souto, Eliana B
Publication year
2019
Publication date
2019
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2333255456
Copyright
© 2019. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.