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Abstract
This work describes a robust, simple method for generating cerebral organoids from human induced pluripotent stem cells by using a chemically defined hydrogel material and chemically defined culture medium. This method greatly facilitates access to cerebral organoid technology, enables scalable applications, and provides a potential pathway to translational applications where defined components are desirable.
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1 Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Bioactive Regenerative Therapeutics, Inc., Two Harbors, Minnesota, USA; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA
2 Bioactive Regenerative Therapeutics, Inc., Two Harbors, Minnesota, USA
3 Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA
4 Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA
5 Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
6 Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
7 Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, Minnesota, USA
8 Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota, USA
9 Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA
10 Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA
11 Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA