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Abstract
Stem cell derived retinal pigment epithelium (RPE) holds promise as a cell replacement therapy for macular degeneration. This work demonstrates the role of the cAMP and transforming growth factor β signaling pathways in RPE epithelialization in vitro. Modulation of these pathways by small molecules leads to increased efficiency of RPE generation with a higher yield.
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Details
1 Pfizer Neuroscience and Pain Research Unit, Pfizer Ltd., Great Abington, Cambridge, United Kingdom
2 Pfizer Worldwide Medicinal Chemistry, Pfizer Ltd., Great Abington, Cambridge, United Kingdom