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© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

[...]these results attract our interest to use the structure of pterostilbene as a scaffold to develop the anti-MRSA infection agent. [...]we believe the insertion of 1,2,3-triazole in the scaffold may lead to the potential active compounds. [...]the MBC value of these two compounds was over 1250 μg/mL. [...]it was speculated that the antibacterial activity of compounds 7d and 7e was to inhibit the growth of MRSA rather than bactericidal action. The anti-MRSA activity decreased in the order of 4d (1.2–2.4 μg/mL) > 5d (312.5–625 μg/mL) > 6d, indicating the derivatives with the phenyl group as the spacer between triazole and carboxylic acid was more active than the benzyl group, which in turn was more active than the phenacyl group with no anti-bacterial activity. [...]from the results among these derivatives, we could speculate that the spacer between triazole and carboxylic acid plays an important role in the inhibition of MRSA.

Details

Title
Design, Synthesis, and Anti-Bacterial Evaluation of Triazolyl-Pterostilbene Derivatives
Author
Kai-Wei, Tang; Shih-Chun, Yang; Chih-Hua Tseng
Publication year
2019
Publication date
2019
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2333829282
Copyright
© 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.