Abstract

Mesenchymal stem cell (MSC)-based therapies are under investigation for tissue repair but suffer from poor cell persistence and engraftment upon transplantation. When entrapped in an adhesive biomaterial, MSC spheroids exhibited improved survival and proangiogenic growth factor secretion in vitro and bone formation in vivo compared with cells in nonadhesive hydrogels. These findings demonstrate the value of deploying MSC spheroids in instructive biomaterials to improve cell function.

Details

Title
Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels
Author
Ho, Steve S 1 ; Murphy, Kaitlin C 1 ; Binder Bernard Y.K. 1 ; Vissers, Caroline B 1 ; Kent, Leach J 2 

 Department of Biomedical Engineering, University of California, Davis, Davis, California, USA 
 Department of Biomedical Engineering, University of California, Davis, Davis, California, USA; Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, California, USA 
Pages
773-781
Section
Enabling Technologies for Cell-Based Clinical Translation
Publication year
2016
Publication date
Jun 2016
Publisher
Oxford University Press
ISSN
21576564
e-ISSN
21576580
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2333897477
Copyright
© 2016. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.