Abstract

A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs) via a ROS-responsive linker, which is encapsulated inside the liposomal system in which the lipid bilayer embeds chlorophyll a (Chla). The UCNP functions as a transducer, converting NIR light into upconversion luminescence for simultaneous imaging and therapy in situ. Functioning as light-harvesting antennas, AuNPs are used to detect the local concentration of ROS for FRET biosensing, while the Chla activates the photosynthesis of H2 gas to scavenge local excess ROS. The results thus obtained indicate the potential of using the Lip NPs in the analysis of biological tissues, restoring their ROS homeostasis, possibly preventing the initiation and progression of diseases.

Hydrogen can be used to reduce the concentration of reactive oxygen species (ROS), but its delivery to diseased tissues is challenging due to its low solubility. Here the authors develop a photosynthesis-inspired FRET nanocomplex to detect and scavenge local excess of ROS in the tissue using photocatalytic hydrogen production.

Details

Title
Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS
Author
Wei-Lin, Wan 1 ; Tian, Bo 1 ; Yu-Jung, Lin 1 ; Korupalli Chiranjeevi 1 ; Ming-Yen, Lu 2 ; Cui Qinghua 1 ; Wan Dehui 1 ; Chang, Yen 3 ; Hsing-Wen, Sung 1   VIAFID ORCID Logo 

1  National Tsing Hua University, Department of Chemical Engineering and Institute of Biomedical Engineering, Frontier Research Center on Fundamental and Applied Sciences of Matters, Hsinchu, Taiwan, ROC (GRID:grid.38348.34) (ISNI:0000 0004 0532 0580) 
2  National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu, Taiwan, ROC (GRID:grid.38348.34) (ISNI:0000 0004 0532 0580) 
3  Tzu Chi University, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Hualien, Taiwan, ROC (GRID:grid.411824.a) (ISNI:0000 0004 0622 7222) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-020-14413-x
ProQuest document ID
2346397082
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.