Abstract

Host genetic susceptibility to leprosy has been intensively investigated over the last decades; however, there are no studies on the role of genetic variants in disease recurrence. A previous initiative identified three recurrent cases of leprosy for which none of the M. leprae strains, as obtained in the first and the second diagnosis, had any known genomic variants associated to resistance to Multidrug therapy; in addition, whole genome sequencing indicated that the same M. leprae was causing two out of the three recurrences. Thus, these individuals were suspected of being particularly susceptible to M. leprae infection, either as relapse or reinfection. To verify this hypothesis, 19 genetic markers distributed across 11 loci (14 genes) classically associated with leprosy were genotyped in the recurrent and in three matching non-recurrent leprosy cases. An enrichment of risk alleles was observed in the recurrent cases, suggesting the existence of a particularly high susceptibility genetic profile among leprosy patients predisposing to disease recurrence.

Details

Title
Human Genetic Susceptibility of Leprosy Recurrence
Author
Uaska Sartori Priscila Verchai 1 ; Penna, Gerson O 2 ; Bührer-Sékula Samira 3 ; Pontes Maria A A 4 ; Gonçalves, Heitor S 4 ; Cruz Rossilene 5 ; Virmond Marcos C L 6 ; Dias-Baptista Ida M F 6 ; Rosa, Patricia S 6 ; Penna Maria L F 7   VIAFID ORCID Logo  ; Medeiros, Fava Vinicius 8 ; Stefani Mariane M A 9 ; Távora, Mira Marcelo 1   VIAFID ORCID Logo 

1  Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição 1155 - Prado Velho, Paraná, Brazil (GRID:grid.412522.2) (ISNI:0000 0000 8601 0541) 
2  Tropical Medicine Centre, University of Brasília, UnB - Brasília, Brazil (GRID:grid.7632.0) (ISNI:0000 0001 2238 5157); Campus Universitário Darcy Ribeiro, S/N, Asa Norte, Brasília - DF, Brasil (GRID:grid.7632.0) (ISNI:0000 0001 2238 5157); Escola Fiocruz de Governo, Fiocruz Brasília, Avenida L3 Norte, s/n, Campus Universitário Darcy Ribeiro, Gleba A, Brazil (GRID:grid.7632.0) (ISNI:0000 0001 2238 5157) 
3  Tropical Pathology and Public Health Institute, Federal University of Goiás, Rua 235 - s/n - Setor Universitário - Goiania, Goiania, Brazil (GRID:grid.411195.9) (ISNI:0000 0001 2192 5801) 
4  Dona Libânia Dermatology Centre, R. Pedro I, 1033 - Centro, Fortaleza, Brazil (GRID:grid.411195.9) 
5  Tropical Dermatology and Venerology, Fundação Alfredo da Matta, Av. Codajás, 24 - Cachoeirinha, Manaus, Brazil (GRID:grid.411195.9) 
6  Lauro Souza Lima Institute, Rodovia Comandante João Ribeiro de Barros, km 225/226, s/n - Distrito Industrial Marcus Vinícius Feliz Machado, Bauru, Brazil (GRID:grid.411195.9) 
7  Epidemiology and Biostatistics Department, Universidade Federal Fluminense, Rua Marquês do Paraná, 303, Centro, Niterói, Brazil (GRID:grid.411173.1) (ISNI:0000 0001 2184 6919) 
8  Infectious Diseases and Immunity in Global Health (IDIGH) Program at the Research Institute of the McGill University Health Centre (RI-MUHC), 1001 Boulevard Décarie, Bioinformatics suite ES1.5561, H4A 3J1., Montreal, Canada (GRID:grid.411173.1) 
9  Escola Fiocruz de Governo, Fiocruz Brasília, Avenida L3 Norte, s/n, Campus Universitário Darcy Ribeiro, Gleba A, Brazil (GRID:grid.7632.0) (ISNI:0000 0001 2238 5157) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-020-58079-3
ProQuest document ID
2348116726
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.