Abstract

Background

Tension-type headache is the most common headache to be seen in clinical practice. Depression is highly prevalent in chronic tension-type headache (CTTH) patients attending the clinical settings. Cognitive impairment and neuroendocrine dysregulation had been reported in patients with depression and patients with CTTH.

Objective

To assess the cognitive performance and investigate its possible relations to neuroendocrine levels in patients with CTTH.

Subjects and methods

Patients with CTTH, depression, and control subjects were recruited. CTTH was diagnosed according to the International Classification of Headache Disorders. Cognitive performance, depression severity, and pain intensity were assessed by the Montreal Cognitive Assessment Arabic version, Beck’s Depression Inventory, and McGill Pain Questionnaire respectively. Blood samples were collected in the morning within 60 min after waking up from 8:00 to 9:00 a.m. to measure serum levels of basal plasma CRH, ACTH, Cortisol, TSH, FT3, and FT4.

Results

Both patients with CTTH and depression had impaired cognitive performance. Patients with CTTH and patients with depression had altered the hypothalamus-pituitary-adrenal axis, and pituitary-thyroid axis. The hormonal levels significantly correlated with cognitive function in patient groups, especially patients with CTTH.

Conclusion

Patients with CTTH had cognitive dysfunction which could be related to neuroendocrine hormonal dysregulation.

Details

Title
Cognitive performance in patients with chronic tension-type headache and its relation to neuroendocrine hormones
Author
Kotb, Mamdouh Ali 1   VIAFID ORCID Logo  ; Kamal, Ahmed M 2 ; Al-Malki Daifallah 3 ; Abd El Fatah Aliaa S 4 ; Ahmed, Yassmin M 5 

1  Prince Sattam bin Abdulaziz University, Neurology Department, College of Medicine, Alkharj, Kingdom of Saudi Arabia (GRID:grid.449553.a); Minia University, Neurology Department, Faculty of Medicine, Minia, Egypt (GRID:grid.411806.a) (ISNI:0000 0000 8999 4945) 
2  Prince Sattam bin Abdulaziz University, Psychiatry Department, College of Medicine, Alkharj, Kingdom of Saudi Arabia (GRID:grid.449553.a); Minia University, Psychiatry Department, Faculty of Medicine, Minia, Egypt (GRID:grid.411806.a) (ISNI:0000 0000 8999 4945) 
3  Prince Sattam bin Abdulaziz University, Neurology Department, College of Medicine, Alkharj, Kingdom of Saudi Arabia (GRID:grid.449553.a) 
4  Minia University, Department of Internal Medicine, Faculty of Medicine, Minia, Egypt (GRID:grid.411806.a) (ISNI:0000 0000 8999 4945) 
5  Minia University, Faculty of Medicine, Minia, Egypt (GRID:grid.411806.a) (ISNI:0000 0000 8999 4945) 
Publication year
2020
Publication date
Jan 2020
Publisher
Springer Nature B.V.
ISSN
11101083
e-ISSN
16878329
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s41983-020-0150-3
ProQuest document ID
2348262381
Copyright
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery is a copyright of Springer, (2020). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.