Abstract

Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.

In this longitudinal study, the authors tracked the course of brain development from birth to adolescence (age 13 years) and examined the effects of very preterm birth. Very preterm children showed slower brain growth from age 0 (term equivalent) to age 7.

Details

Title
Tracking regional brain growth up to age 13 in children born term and very preterm
Author
Thompson, Deanne K 1   VIAFID ORCID Logo  ; Matthews, Lillian G 2   VIAFID ORCID Logo  ; Alexander, Bonnie 3 ; Lee, Katherine J 4 ; Kelly, Claire E 3   VIAFID ORCID Logo  ; Adamson, Chris L 5 ; Hunt, Rod W 6 ; Cheong Jeanie L Y 7   VIAFID ORCID Logo  ; Spencer-Smith, Megan 8   VIAFID ORCID Logo  ; Neil, Jeffrey J 9 ; Seal, Marc L 10 ; Inder, Terrie E 11 ; Doyle, Lex W 12   VIAFID ORCID Logo  ; Anderson, Peter J 8   VIAFID ORCID Logo 

1  Murdoch Children’s Research Institute, Victorian Infant Brain Study (VIBeS), Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); Murdoch Children’s Research Institute, Developmental Imaging, Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); University of Melbourne, Department of Paediatrics, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X); Florey Institute of Neuroscience and Mental Health, Parkville, Australia (GRID:grid.418025.a) (ISNI:0000 0004 0606 5526) 
2  Brigham and Women’s Hospital, Harvard Medical School, Department of Pediatric Newborn Medicine, Boston, USA (GRID:grid.418025.a) 
3  Murdoch Children’s Research Institute, Victorian Infant Brain Study (VIBeS), Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); Murdoch Children’s Research Institute, Developmental Imaging, Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X) 
4  Murdoch Children’s Research Institute, Victorian Infant Brain Study (VIBeS), Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); University of Melbourne, Department of Paediatrics, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X); Murdoch Children’s Research Institute, Clinical Epidemiology and Biostatistics Unit, Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X) 
5  Murdoch Children’s Research Institute, Developmental Imaging, Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X) 
6  Murdoch Children’s Research Institute, Victorian Infant Brain Study (VIBeS), Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); University of Melbourne, Department of Paediatrics, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X); Royal Children’s Hospital, Neonatal Medicine, Parkville, Australia (GRID:grid.416107.5) (ISNI:0000 0004 0614 0346) 
7  Murdoch Children’s Research Institute, Victorian Infant Brain Study (VIBeS), Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); Royal Women’s Hospital, Parkville, Australia (GRID:grid.416259.d) (ISNI:0000 0004 0386 2271); University of Melbourne, Department of Obstetrics and Gynaecology, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X) 
8  Murdoch Children’s Research Institute, Victorian Infant Brain Study (VIBeS), Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); Monash University, Turner Institute for Brain and Mental Health, Clayton, Australia (GRID:grid.1002.3) (ISNI:0000 0004 1936 7857) 
9  Washington University School of Medicine, Department of Pediatric Neurology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002) 
10  Murdoch Children’s Research Institute, Developmental Imaging, Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); University of Melbourne, Department of Paediatrics, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X) 
11  Murdoch Children’s Research Institute, Victorian Infant Brain Study (VIBeS), Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); Brigham and Women’s Hospital, Harvard Medical School, Department of Pediatric Newborn Medicine, Boston, USA (GRID:grid.1058.c) 
12  Murdoch Children’s Research Institute, Victorian Infant Brain Study (VIBeS), Parkville, Australia (GRID:grid.1058.c) (ISNI:0000 0000 9442 535X); University of Melbourne, Department of Paediatrics, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X); Royal Women’s Hospital, Parkville, Australia (GRID:grid.416259.d) (ISNI:0000 0004 0386 2271); University of Melbourne, Department of Obstetrics and Gynaecology, Parkville, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-020-14334-9
ProQuest document ID
2350892622
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.