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Abstract
Background and objectives: Chronic musculoskeletal (MS) pain is common in chronic kidney disease (CKD) patients. The association of chronic MS pain and CKD progression has not yet been established.
Method: We conducted a prospective cohort study to evaluate the association of chronic MS pain and CKD progression of pre-dialysis CKD patients.
Result: A total of 53.2% of pre-dialysis CKD patients had chronic MS pain. Patients classified as progression and non-progression had a similar prevalence of chronic MS pain at baseline, and similar baseline use of NSAIDs and Chinese herbal medicines. Univariate Cox analysis indicated that chronic MS pain and baseline NSAID or Chinese herbal medicine use were not significantly associated with progression of CKD. But multivariate Cox regression found chronic MS pain was independently significantly associated with all-cause mortality (HR, 2.912, 95% CI, 1.004–8.444; p = .049). However, serum levels of hs-CRP were similar between those chronic MS pain patients and without chronic MS pain patients (4.96 ± 9.4 vs. 4.25 ± 13.3 mg/L, p = .535).
Conclusion: The CKD patients with chronic MS pain was independently and significantly associated with all-cause mortality, but not independently and significantly associated with CKD progression and composite endpoints. The inflammatory marker-hs-CRP was similar between CKD patients with and without chronic MS pain.
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Details
1 Division of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan;; Taoyuan School of Medicine, the Graduate institute of Clinical Medical Sciences, Chang Gung University Medical College, Keelung, Taiwan;
2 Division of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan;
3 Laboratory of Epidemiology, Department of Health Care Management, Chang Gung University, Taipei, Taiwan;
4 Division of Cardiology, Chang Gung Memorial Hospital, Keelung, Taiwan;
5 Division of Nephrology, Taipei Medical University Hospital, Taipei, Taiwan;; Department of Internal Medicine, Taipei Medical University, Taipei, Taiwan