Abstract

Morphogenetic events that occur during development and regeneration are energy demanding processes requiring profound rearrangements in cell architecture, which need to be coordinated in timely fashion with other cellular activities, such as proliferation, migration and differentiation. In the last 15 years, it has become evident that autophagy, an evolutionarily-conserved catabolic process that mediates the lysosomal turnover of organelles and macromolecules, is an essential “tool” to ensure remodelling events that occur at cellular and tissue levels. Indeed, studies in several model organisms have shown that the inactivation of autophagy genes has a significant impact on embryogenesis and tissue regeneration, leading to extensive cell death and persistence of unnecessary cell components. Interestingly, the increased understanding of the mechanisms that confers selectivity to the autophagic process has also contributed to identifying development-specific targets of autophagy across species. Moreover, alternative ways to deliver materials to the lysosome, such as microautophagy, are also emerging as key actors in these contexts, providing a more complete view of how the cell component repertoire is renovated. In this review, we discuss the role of different types of autophagy in development and regeneration of invertebrates and vertebrates, focusing in particular on its contribution in cnidarians, platyhelminthes, nematodes, insects, zebrafish and mammals.

Details

Title
Autophagy in development and regeneration: role in tissue remodelling and cell survival
Author
Tettamanti, G 1   VIAFID ORCID Logo  ; Carata, E 2 ; Montali, A 1 ; Dini, L 3 ; Fimia, G M 4   VIAFID ORCID Logo 

 Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy 
 Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy 
 Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy 
 Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy; Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases IRCCS “Lazzaro Spallanzani”, Rome, Italy 
Pages
113-131
Publication year
2019
Publication date
Dec 2019
Publisher
Taylor & Francis Ltd.
ISSN
24750255
e-ISSN
24750263
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2353563992
Copyright
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.