It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Objective: To longitudinally evaluate the impact of change in physical activity or change in body mass index (BMI) over time on the risk of developing heart failure (HF) in women without a previous diagnosis of HF.
Design and setting: Longitudinal, observational, prospective study of women in Gothenburg, Sweden. Data on BMI and level of physical activity were collected from examinations 1968–1992 and hospital diagnoses and mortality data were ascertained from 1980 to 2012.
Subjects: Data were obtained from 1749 women included in the Prospective Population Study of Women in Gothenburg.
Main outcome measures: Hazard ratio (HR) for HF was calculated, using a Cox regression model.
Results: Women with stable high physical activity during 1968–1980 and 1980–1992 reduced their risk of subsequent HF compared to the non-active women (for 1968–1980 HR 0.66, 95% Confidence Interval (CI) 0.44–0.99 and for 1980–1992 HR 0.47, 95% CI 0.29–0.74). Women with increasing levels of physical activity during 1980–1992 reduced their risk of HF compared to the non-active women (HR 0.40, 95% CI 0.22–0.72). Increase in BMI from overweight to obesity during 1968–1980 predicted increased risk of developing HF (HR 1.93, 95% CI 1.18–3.14).
Conclusions: Reduced risk of future HF in healthy women may be achieved by remaining physically active from young middle age and throughout life or by increasing the level of physical activity. This is particularly important for sedentary women in middle age. The role of physical activity in preventing the development of obesity must be taken into account.
- Key points
A sedentary lifestyle and obesity are risk factors for developing heart failure (HF) in women.
The risk of developing HF may be reduced by increasing the level of activity in sedentary middle-aged women.
For younger women, avoiding obesity is most important to reduce the risk of later HF.
Primary care has a key role in guiding women towards the most effective lifestyle changes to prevent development of HF.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Primary Health Care, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
2 School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden;
3 Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden