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© Saudi Medical Journal 2019. This work is licensed under the Creative Commons  Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Objectives:

To determine the ideal number of sputum acid-fast bacilli (AFB) smears and polymerase chain reaction (PCR) required for discontinuing tuberculosis (TB) isolation among patients with suspected pulmonary TB.

Methods:

This was a single-center, record-based retrospective study of all admitted patients diagnosed with culture-proven pulmonary TB between 2010 and 2018. The study was conducted at Prince Sultan Military Medical City (PSMMC) in Riyadh, Saudi Arabia, a large tertiary care center consisting of 1,200 beds. Data were obtained from our TB notification records. Patients with smear-positive TB were investigated. Only the first 3 sputum smears for AFB were included in the analysis. The PCR results for Mycobacterium tuberculosis (MTB) were also included in the study. The incremental yield of the second and third smears was assessed.

Results:

Overall, 240 patients were MTB-culture positive. A total of 126 (52.5%) patients were smear and culture positive, whereas 114 were culture positive but smear negative. Of 126 patients who were AFB smear positive, 98 (77.8%) were detected in the first specimen, 13 (10.3%) in the second specimen, and only 9 (7.1%) in the third specimen. Polymerase chain reaction for MTB was positive in 122 (96.8%) smear-positive patients. Four patients did not undergo a PCR test.

Conclusion:

A single Xpert MTB/resistance to rifampicin test detected all smear-positive patients, whereas the third smear did not significantly contribute to MTB isolation.

Details

Title
Isolation and deisolation of patients admitted with presumptive pulmonary tuberculosis
Author
Elzein, Fatehi E 1 ; Alsherbeeni Nisreen 1 ; Mursi Mohammed 1 ; Algoblan, Shoug F 1 ; Abuzaid, Abuzaid A 1 ; Albarrak, Ali M 1 

 From the Infectious Diseases Unit (Elzein, Alsherbeeni, Mursi, Algoblan, Albarrak), Prince Sultan Military Medical City and from the Ministry of Health (Abuzaid), Riyadh, Kingdom of Saudi Arabia 
Pages
1008-1012
Publication year
2019
Publication date
Oct 2019
Publisher
Prince Sultan Military Medical City (PSMMC)
ISSN
03795284
e-ISSN
16583175
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2365238416
Copyright
© Saudi Medical Journal 2019. This work is licensed under the Creative Commons  Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.