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Abstract
Doxorubicin entrapped carbon dots (DOX-CDs) were prepared for bioimaging and enhanced intracellular drug delivery. The CDs were synthesized via the hydrothermal method using citrate and urea under 200 °C for 1 h. Then, DOX was successfully conjugated on the CDs via physicochemical interactions. The DOX-CDs exhibited good crystal structure, remarkable aqueous stability, excellent photoluminescence property, and a high quantum yield of 93%. The fluorescent images revealed that the DOX-CDs could be readily taken up by the cancer cells for cell labeling. Furthermore, endo-lysosomal pH-assisted DOX release behavior was observed from DOX-CDs, and the cytotoxicity of DOX-CDs was confirmed by the MTS assay against H0-8910 ovarian cancer cells. In addition, the CDs indicated bright fluorescent signal in the animal imaging test and demonstrated low toxicity after administration for 7 and 21 days. Therefore, the prepared CDs could be a promising imaging probe for biomedical imaging and intracellular drug delivery.
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Details
1 Xuzhou Medical University, School of Medical Imaging, Xuzhou, People’s Republic of China (GRID:grid.417303.2) (ISNI:0000 0000 9927 0537)
2 Xuzhou Medical University, School of Medical Imaging, Xuzhou, People’s Republic of China (GRID:grid.417303.2) (ISNI:0000 0000 9927 0537); Affiliated Hospital of Xuzhou Medical University, Department of Radiology, Xuzhou, People’s Republic of China (GRID:grid.413389.4)
3 Affiliated Hospital of Xuzhou Medical University, Department of Radiology, Xuzhou, People’s Republic of China (GRID:grid.413389.4)