Abstract

Early 2 factor (E2F) family transcription factors participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and metabolism. Circadian rhythms influence many of these phenomena. Here we find that a mammalian circadian rhythm component, Cryptochrome 2 (CRY2), regulates E2F family members. Furthermore, CRY1 and CRY2 cooperate with the E3 ligase complex SKP-CULLIN-FBXL3 (SCFFBXL3) to reduce E2F steady state protein levels. These findings reveal an unrecognized molecular connection between circadian clocks and cell cycle regulation and highlight another mechanism to maintain appropriate E2F protein levels for proper cell growth.

Details

Title
Cryptochromes modulate E2F family transcription factors
Author
Chan, Alanna B 1 ; Huber, Anne-Laure 2 ; Lamia, Katja A 1 

 The Scripps Research Institute, Department of Molecular Medicine, La Jolla, USA (GRID:grid.214007.0) (ISNI:0000000122199231) 
 The Scripps Research Institute, Department of Molecular Medicine, La Jolla, USA (GRID:grid.214007.0) (ISNI:0000000122199231); Centre de Recherche en Cancerologie de Lyon, Lyon, France (GRID:grid.462282.8) (ISNI:0000 0004 0384 0005) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2371807109
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.