Abstract

We developed the microfluidic co-culture platform to study photothermal therapy applications. We conjugated folic acid (FA) to target breast cancer cells using reduced graphene oxide (rGO)-based functional nanomaterials. To characterize the structure of rGO-based nanomaterials, we analyzed the molecular spectrum using UV–visible and Fourier-transform infrared spectroscopy (FT-IR). We demonstrated the effect of rGO-FA-based nanomaterials on photothermal therapy of breast cancer cells in the microfluidic co-culture platform. From the microfluidic co-culture platform with breast cancer cells and human umbilical vein endothelial cells (HUVECs), we observed that the viability of breast cancer cells treated with rGO-FA-based functional nanomaterials was significantly decreased after near-infrared (NIR) laser irradiation. Therefore, this microfluidic co-culture platform could be a potentially powerful tool for studying cancer cell targeting and photothermal therapy.

Details

Title
rGO nanomaterial-mediated cancer targeting and photothermal therapy in a microfluidic co-culture platform
Author
Mun, Seok Gyu 1 ; Choi, Hyung Woo 2 ; Lee Jong Min 3 ; Lim, Jae Hyun 1 ; Ha Jang Ho 3 ; Min-Jung, Kang 2 ; Eun-Joong, Kim 2 ; Kang, Lifeng 4   VIAFID ORCID Logo  ; Chung, Bong Geun 3   VIAFID ORCID Logo 

1  Sogang University, Department of Biomedical Engineering, Seoul, Korea (GRID:grid.263736.5) (ISNI:0000 0001 0286 5954) 
2  Sogang University, Research Center, Seoul, Korea (GRID:grid.263736.5) (ISNI:0000 0001 0286 5954) 
3  Sogang University, Department of Mechanical Engineering, Seoul, Korea (GRID:grid.263736.5) (ISNI:0000 0001 0286 5954) 
4  University of Sydney, School of Pharmacy, Sydney, Australia (GRID:grid.1013.3) (ISNI:0000 0004 1936 834X) 
Publication year
2020
Publication date
Dec 2020
Publisher
Springer Nature B.V.
e-ISSN
21965404
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s40580-020-0220-3
ProQuest document ID
2377655030
Copyright
Nano Convergence is a copyright of Springer, (2020). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.