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© 2017. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (H2O2) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, ganoderma lucidum polysaccharides remarkably suppressed H2O2-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2. These findings suggested that ganoderma lucidum polysaccharides regulate expression of apoptosis-associated proteins, inhibit oxidative stress-induced neuronal apoptosis and, therefore, have significant neuroprotective effects.

Details

Title
Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis
Author
Xin-zhi Sun 1 ; Liao, Ying 2 ; Li, Wei 3 ; Li-mei, Guo 4 

 Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 
 Department of Public Security Technology, Railway Police College, Zhengzhou, Henan Province; Department of Pathology, Peking University Health Science Center, Beijing 
 Department of Public Security Technology, Railway Police College, Zhengzhou, Henan Province 
 Department of Pathology, Peking University Health Science Center, Beijing 
Pages
953-958
Publication year
2017
Publication date
Jun 2017
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
16735374
e-ISSN
18767958
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2382700098
Copyright
© 2017. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.