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© 2015. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Previous animal studies of cauda equina injury have primarily used rat models, which display significant differences from humans. Furthermore, most studies have focused on electrophysiological examination. To better mimic the outcome after surgical repair of cauda equina injury, a novel animal model was established in the goat. Electrophysiological, histological and magnetic resonance imaging methods were used to evaluate the morphological and functional outcome after cauda equina injury and end-to-end suture. Our results demonstrate successful establishment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgical repair of cauda equina injury.

Details

Title
Large animal models of human cauda equina injury and repair: evaluation of a novel goat model
Author
Wen-tao, Chen 1 ; Pei-xun Zhang 1 ; Xue, Feng 1 ; Xiao-feng, Yin 1 ; Cao-yuan, Qi 2 ; Ma, Jun 2 ; Chen, Bo 1 ; You-lai, Yu 1 ; Jiu-xu Deng 1 ; Bao-guo, Jiang 1 

 Department of Trauma and Orthopedics, Peking University People′s Hospital, Beijing 
 Department of Radiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 
Pages
60-64
Publication year
2015
Publication date
Jan 2015
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
16735374
e-ISSN
18767958
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2382734245
Copyright
© 2015. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.