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© 2015. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majority of functional magnetic resonance imaging studies focus on the motor dysfunction and the acute stage of ischemic stroke. This study recruited 15 right-handed ischemic stroke patients at subacute stage (15 days to 11.5 weeks) and 15 age-matched healthy participants. A resting-state functional magnetic resonance imaging scan was performed on each subject to detect cerebral activity. Regional homogeneity analysis was used to investigate the difference in cerebral activities between ischemic stroke patients and healthy participants. The results showed that the ischemic stroke patients had lower regional homogeneity in anterior cingulate and left cerebrum and higher regional homogeneity in cerebellum, left precuneus and left frontal lobe, compared with healthy participants. The experimental findings demonstrate that the areas in which regional homogeneity was different between ischemic stroke patients and healthy participants are in the cerebellum, left precuneus, left triangle inferior frontal gyrus, left inferior temporal gyrus and anterior cingulate. These locations, related to the motor, sensory and emotion areas, are likely potential targets for the neural regeneration of subacute ischemic stroke patients.

Details

Title
Changes of resting cerebral activities in subacute ischemic stroke patients
Author
Wu, Ping 1 ; Zeng, Fang 1 ; Yong-xin, Li 2 ; Bai-li, Yu 3 ; Li-hua, Qiu 4 ; Qin, Wei 5 ; Li, Ji 3 ; Yu-mei, Zhou 1 ; Fan-rong, Liang 1 

 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province 
 Institute of Clinical Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 
 The First Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province 
 Radiology Department, West China Hospital of Sichuan University, Chengdu, Sichuan Province 
 Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi′an, Shaanxi Province 
Pages
760-765
Publication year
2015
Publication date
May 2015
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
16735374
e-ISSN
18767958
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2382740102
Copyright
© 2015. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.