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© 2015. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Ligustrazine (2,3,5,6-tetramethylpyrazine) is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease. The mechanism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present. This study summarizes its protective effect, the optimum time window of administration, and the most effective mode of administration for clinical treatment of cerebral ischemia/reperfusion injury. We examine the effects of ligustrazine on suppressing excitatory amino acid release, promoting migration, differentiation and proliferation of endogenous neural stem cells. We also looked at its effects on angiogenesis and how it inhibits thrombosis, the inflammatory response, and apoptosis after cerebral ischemia. We consider that ligustrazine gives noticeable protection from cerebral ischemia/reperfusion injury. The time window of ligustrazine administration is limited. The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, CXC137 and CXC195 after cerebral ischemia were better than ligustrazine.

Details

Title
Ligustrazine monomer against cerebral ischemia-reperfusion injury
Author
Hai-jun Gao 1 ; Peng-fei, Liu 2 ; Pei-wen, Li 2 ; Zhuo-yan, Huang 3 ; Feng-bo, Yu 4 ; Ting Lei 2 ; Chen, Yong 2 ; Cheng, Ye 2 ; Qing-chun Mu 5 ; Hai-yan, Huang 2 

 Department of Neurosurgery, First Bethune Hospital of Jilin University, Changchun, Jilin Province; Department of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province 
 Department of Neurosurgery, First Bethune Hospital of Jilin University, Changchun, Jilin Province 
 Clinical Medical College of Beihua University, Jilin, Jilin Province 
 School of Pharmacy, Mudanjiang Medical University, Mudanjiang, Heilongjiang Province 
 Department of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province 
Pages
832-840
Publication year
2015
Publication date
May 2015
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
16735374
e-ISSN
18767958
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2382750131
Copyright
© 2015. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.