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© 2012. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1, 2, and 4 weeks after injection. There was no difference between left (control) and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6 mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6 mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe. Research Highlights

  1. Previous studies have reported vitreous space injection of ketorolac tromethamine to observe neurotoxicity on the retina. However, suprachoroidal injection of ketorolac tromethamine has not been reported.
  2. A single suprachoroidal injection of 6 mg ketorolac tromethamine in rabbits showed no significant influence on electroretinograms and retinal morphological structures.
  3. Results suggested that suprachoroidal injection of 6 mg ketorolac tromethamine in rabbits is safe.

Details

Title
Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage
Author
Liu, Sumeng 1 ; Liu, Wu 2 ; Ma, Yaling 1 ; Liu, Kegao 2 ; Wang, Meizi 2 

 General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region 
 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730 
Pages
2770-2777
Publication year
2012
Publication date
Dec 2012
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
16735374
e-ISSN
18767958
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2382806877
Copyright
© 2012. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.