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© 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradable polymeric PLGA nanoparticles constitute a suitable alternative to topical eye administration, as they can improve ocular bioavailability and simultaneously reduce drug induced side effects. Moreover, their prolonged drug release can enhance patient treatment adherence as they require fewer administrations. Therefore, several formulations of PLGA based nanoparticles encapsulating dexibuprofen (active enantiomer of Ibuprofen) were prepared using the solvent displacement method employing different surfactants. The formulations have been characterized and their interactions with a customized lipid corneal membrane model were studied. Ex vivo permeation through ocular tissues and in vivo anti-inflammatory efficacy have also been studied.

Details

Title
Dexibuprofen Biodegradable Nanoparticles: One Step Closer towards a Better Ocular Interaction Study
Author
Sánchez-López, Elena  VIAFID ORCID Logo  ; Esteruelas, Gerard; Ortiz, Alba; Espina, Marta  VIAFID ORCID Logo  ; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana Cristina  VIAFID ORCID Logo  ; Ettcheto, Miren  VIAFID ORCID Logo  ; Camins, Antoni  VIAFID ORCID Logo  ; Alsafi, Zaid; Souto, Eliana B  VIAFID ORCID Logo  ; García, Maria Luisa; Pujol, Montserrat
First page
720
Publication year
2020
Publication date
2020
Publisher
MDPI AG
e-ISSN
20794991
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2389482911
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.