Abstract

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

In this Comment, Ngan Huang et al. discuss recent advances in cardiovascular tissue engineering and some of the main challenges that remain in translating these advances to the clinic. The authors propose future direction for the field to focus research efforts.

Details

Title
Big bottlenecks in cardiovascular tissue engineering
Author
Huang, Ngan F 1   VIAFID ORCID Logo  ; Serpooshan Vahid 2 ; Morris, Viola B 3 ; Sayed Nazish 4 ; Gaspard, Pardon 5 ; Abilez, Oscar J 6   VIAFID ORCID Logo  ; Nakayama, Karina H 1 ; Pruitt, Beth L 7 ; Wu, Sean M 8 ; Young-sup, Yoon 3 ; Zhang, Jianyi 9 ; Wu, Joseph C 8 

1  Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Stanford University School of Medicine, Department of Cardiothoracic Surgery, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Veteran Affairs Palo Alto Health Care System, Palo Alto, USA (GRID:grid.280747.e) (ISNI:0000 0004 0419 2556) 
2  Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, USA (GRID:grid.470935.c); Emory University School of Medicine, Department of Pediatrics, Atlanta, USA (GRID:grid.189967.8) (ISNI:0000 0001 0941 6502) 
3  Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, USA (GRID:grid.470935.c); Division of Cardiology, Emory University, Department of Medicine, Atlanta, USA (GRID:grid.189967.8) (ISNI:0000 0001 0941 6502) 
4  Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956) 
5  Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Stanford University, Department of Bioengineering, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956) 
6  Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Stanford University School of Medicine, Division of Cardiovascular Medicine, Department of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956) 
7  Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Stanford University, Department of Bioengineering, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Stanford University, Department of Mechanical Engineering, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); University of California at Santa Barbara, Departments of Mechanical Engineering; BioMolecular Science and Engineering; and Molecular, Cellular and Developmental Biology, Santa Barbara, USA (GRID:grid.133342.4) (ISNI:0000 0004 1936 9676) 
8  Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Stanford University School of Medicine, Division of Cardiovascular Medicine, Department of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956) 
9  University of Alabama at Birmingham, Department of Bioengineering, School of Medicine, Birmingham, USA (GRID:grid.265892.2) (ISNI:0000000106344187) 
Publication year
2018
Publication date
2018
Publisher
Nature Publishing Group
e-ISSN
23993642
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s42003-018-0202-8
ProQuest document ID
2389705328
Copyright
© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.