Prone positioning combined with high-flow nasal cannula in severe noninfectious ARDS

Abstract

First of all, which etiology of acute respiratory distress syndrome (ARDS) should be the most appropriate group treated with prone position (PP) combined with high-flow nasal cannula (HFNC)? PP is a respiratory support technique but not for treating the causative disease which induced ARDS. [...]as reported in the case series of Perez-Nieto et al., some group of noninfectious ARDS caused by autoimmune diseases (such as lupus pneumonitis) may need a longer duration of disease resolving than infectious disease and may present with deterioration even under PP and HFNC therapy. [...]patients with PaO2/FiO2 < 100 may face a delayed intubation and worse outcome. [...]the safety and efficacy of PP combined with HFNC in noninfectious diseases which cause severe ARDS in patients with a PaO2/FiO2 < 100 also need evaluation. 1.