Abstract
{Figure 1}{Figure 2}{Figure 3}{Figure 4} No treatment was prescribed and skin biopsies were performed from the hyperkeratotic ear lesions and bullae on the back in order to confirm the clinical suspicion of acrokeratosis paraneoplastica and discard a concomitant primary autoimmune bullous disorder, especially bullous pemphigoid. The histological features of Bazex syndrome are often non-specific or show necrotic keratinocytes causing a vacuolization of the basal zone, thus leading to the creation of subepidermal clefts, clinically presenting as bullae, as we described. [1] Deposits of IgA, IgG and C3 in a nonspecific pattern along the epidermal basement membrane have been reported in some cases, supporting the theory that bulla formation is most probably part of the changes that may affect the skin of patients with Bazex syndrome.
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1 Division of Dermatology, University Hospital of Marqués de Valdecilla, University of Cantabria, Santander, Cantabria
2 Division of Oncology, University Hospital of Marqués de Valdecilla, University of Cantabria, Santander, Cantabria
3 Division of Pathology, University Hospital of Marqués de Valdecilla, University of Cantabria, Santander, Cantabria