Abstract

Background

Gastric cancer is one of the most common cancers leading to high cancer mortality. MicroRNA-484 (miR-484) has been evaluated as a biomarker for various types of cancers. The subject of this study is to investigate the functional role of miR-484 in gastric cancer.

Methods

The expression of miR-484 in gastric cancer was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) assay. Kaplan-Meier survival and Cox regression analyses were employed to explore the prognostic significance of miR-484 in gastric cancer. The functional role of miR-484 in gastric cancer was determined by CCK-8 and Transwell assays.

Results

The results showed that miR-484 was significantly downregulated in gastric cancer tissues and cell lines. The downregulation of miR-484 was closely related to differentiation, lymph node metastasis, TNM stage, and poor prognosis. Cox regression analyses demonstrated that miR-484 was an independent prognosis indicator for gastric cancer patients. Additionally, the downregulation of miR-484 enhanced cell proliferation, migration, and invasion in gastric cancer cells.

Conclusion

These data demonstrated that miR-484 can serve as a potential prognostic biomarker and therapeutic target for gastric cancer and it may be involved in the progression of gastric cancer.

Details

Title
Downregulation of miR-484 is associated with poor prognosis and tumor progression of gastric cancer
Author
Li, Ying; Liu, Yusong; Yao, Jie; Li, Rui; Fan, Xiaocheng
Pages
1-7
Section
Research
Publication year
2020
Publication date
2020
Publisher
BioMed Central
e-ISSN
1746-1596
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13000-020-00946-8
ProQuest document ID
2391278160
Copyright
© 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.